Integrative Physiology/Experimental Medicine Chylomicronemia Elicits Atherosclerosis in Mice—Brief Report
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چکیده
Objective—The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1 / ), which manifest severe chylomicronemia as a result of defective lipolysis. Methods and Results—Gpihbp1 / mice on a chow diet have plasma triglyceride and cholesterol levels of 2812 209 and 319 27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient “apo-B48–only” mice and Gpihbp1-deficient “apo-B100–only” mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48– and apo-B100–containing lipoproteins. Conclusions—Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48 – and apo-B100 – containing lipoproteins. (Arterioscler Thromb Vasc Biol. 2010;30:20-23.)
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Integrative Physiology/Experimental Medicine Despite Antiatherogenic Metabolic Characteristics, SCD1-Deficient Mice Have Increased Inflammation and Atherosclerosis
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